| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Fabrication and Characterisation of Two-layered Synthetic Titanium-Chitosan Bone Scaffolds |
| Author(s) |
Lemiha Yildizbakan, Vasiliki C. Panagiotopoulou, Neelam Iqbal, Ngoc Do, Elena Jones, Peter V. Giannoudis, Animesh Jha, Dina Abdul Aziz |
| On-Site Speaker (Planned) |
Lemiha Yildizbakan |
| Abstract Scope |
Infection after bone fracture is a common complication that compromises the healing of the damaged bone and may even cause non-union. Infection can also affect the surrounding blood supply, influencing cell growth.
The aim of this study was to fabricate and characterize osteogenic and antibacterial bone-mimicking composite scaffolds.
The exterior, cortical-like, and porous part was fabricated using titanium powder with 10% iron-doped brushite mineral. The interior,trabecular-like part was fabricated from chitosan, iron-doped brushite, and cerium oxide. The cortical and trabecular components were integrated as one physical structure via freeze-drying. The scaffolds were characterized for their physico-chemical, structural, osteogenic, and antibacterial properties.
The minerals and multilayered scaffolds were characterized using light-based techniques (Raman, FTIR, UV-VIS spectroscopy), SEM, Zeta Potential, and X-ray diffraction. The osteogenic properties of the scaffolds were investigated using cytotoxicity and proliferation. The antibacterial properties of the scaffolds were studied against the most common bacteria in bone infection. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Titanium |