| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
Stretchable and Mechanochemically Active Hydrogels |
| Author(s) |
Jamie J. Kruzic, Yuwan Huang, Alaa Ajam, Zihao Li, P. Bhakthi Jayathilaka, Md Shariful Islam , Chavinya Ranaweera, Meredith Silberstein, Kristopher Kilian |
| On-Site Speaker (Planned) |
Jamie J. Kruzic |
| Abstract Scope |
Inspired by how forces in biological tissues guide their functions in-vivo, we have developed bioinspired hydrogels where an applied force facilitates molecular changes that include: i) molecule immobilization from the surrounding environment, ii) molecule release into the environment, or iii) molecular changes that can be external sensed. We have incorporated these mechanochemistry concepts into covalently bonded poly(ethylene glycol) and polyacrylamide hydrogels. Furthermore, recognizing that single covalent network hydrogels suffer from inherent brittleness that make them poor choices for load bearing bioengineering applications, we have reinforced our mechanochemically active networks with physically bonded alginate networks to create tough and stretchable double network hydrogels that mimic the interpenetrating networks of biomolecules found in living tissue. This presentation will report on the mechanical and functional properties of our mechanochemically active double network hydrogels along with examples of how the magnitude of the mechanical forces/strains can be used to modulate the functional response. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Polymers, Mechanical Properties |