| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
The Effect of Metastasis on Mechanical Competence of Human Trabecular Bone |
| Author(s) |
Hanwen Fan, Hutomo Tanato, Yuxiao Zhou |
| On-Site Speaker (Planned) |
Hanwen Fan |
| Abstract Scope |
Bone metastasis is the spread of cancer cells from a primary tumor site to the bone. Spine is the most frequent site of human skeletal metastasis due to the porous structure and unique cellular environment of the trabecular bone, making its study crucial for a large population of cancer patients. Changes in the mechanical properties of the trabecular bone due to metastasis can be used as diagnostic and prognostic indicators, and knowledge of the mechanical properties of metastatic lesions can aid in treatment planning for personalized therapy. In this study, we presented mechanical testing combined with micro-computed tomography (micro-CT) to image the human spine vertebrae and performed digital volume correlation (DVC) to measure the full 3D strain and deformation. As the result, we found significant difference in trabecular bone microstructure and mechanical properties with quantitatively comparison between healthy spine and metastatic spine. |
| Proceedings Inclusion? |
Planned: |