| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Nanostructural Bone Remodeling at the Interface to Mg Implants |
| Author(s) |
Helga C. Lichtenegger, Thomas Bretschneider, Annelie Weinberg, Nicole Sommer, Omer Suljevic, Christian Hellmich, Lukas Pircher, Nicole Zechmann, Tilman Gruenewald, Irene Rodriguez, Andreas Menzel |
| On-Site Speaker (Planned) |
Helga C. Lichtenegger |
| Abstract Scope |
Bio-resorbable magenisum implants have moved into the focus of research in recent years. Since bone is a complex, highly adaptive material and known to react to mechanical stimuli and chemical influences, implant placement and successive degradation alters the bone structure.
Here we study the changes of the nanostructure of rat bone in response to the presence and different degradation stages of Mg implants by Small Angle X-ray Scattering (SAXS), Small-Angle Scattering Tensor Tomography (SASTT) and electron microscopy. We correlate our results with local mechanicl properties and first results from mechanical modeling.
We find that the local preferred orientation of the collagen-mineral composite is highly sensitve to changing load situation. Experiments involving physical training of rats show a pronounced influence on the bone healing. This type of knowledge is also expected to be highly relevant for clinical application and could be used to optimize patient recovery and mobility. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Magnesium, Mechanical Properties |