| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Engineered Porosity Bone Scaffold Bioceramics via Directional Freeze Casting |
| Author(s) |
Komalakrushna Hadagalli, Bikramjit Basu, Rajendra K Bordia |
| On-Site Speaker (Planned) |
Komalakrushna Hadagalli |
| Abstract Scope |
Hydroxyapatite based porous scaffold’s excellent biocompatibility and osteoconductivity have made this material widely used in bone tissue engineering. We have investigated engineered porosity bone scaffold bioceramics via freeze cast with tunable porosity and pore architecture. It leads to hierarchical porosity with interconnected micro- and aligned macro-pores. Porous scaffolds were sintered at 1250, 1350 and 1450 °C, for 2 h to control the micro and macro porosity. Scaffolds were prepared with 10, 25 and 50 vol.% of HA powder in the slurry and the physical and mechanical properties were compared. Microstructure of interconnected lamellar pore channels examined by SEM and phase purity by XRD. As HA content was increased from 10 to 50 vol.%, the porosity decreased from 80 to 56%. For the 56% porosity samples, the compressive strength and modulus are comparable to cancellous bone. In vitro and in vivo investigations are underway to determine the potential of these scaffolds. |