| About this Abstract |
| Meeting |
2021 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Negative Compressibility Architected Materials for Novel Cardiac Patches |
| Author(s) |
Juan Sebastian Rincon Tabares, David Restrepo, Juan Camilo Velasquez, Hai-Chao Han |
| On-Site Speaker (Planned) |
Juan Sebastian Rincon Tabares |
| Abstract Scope |
Myocardial infarction (MI) produces a deterioration of the pump function, leading to heart failure. Currently, Cardiac patches (CPs) are used to strengthen the infarcted wall to improve cardiac function post-MI. However, CPs have two major limitations: (i) CPs can only provide passive support to the scar tissue and no ability to assist heart contraction. (ii) CPs need to be stiff enough to provide sufficient support but cannot be too stiff to limit diastolic filling. It is of clinical interest to design new materials to fulfill these limitations. In this work, we present a new architected material that generates localized shrinkage (contraction) when subject to tension from surrounding heart wall tissue contraction, so it can assist heart contraction (enhance systolic function) and conform better to the natural heart movements and mechanical properties. Specifically, we will discuss the design, mechanical features, and limitations of such material. |
| Proceedings Inclusion? |
Planned: |