| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Stimuli-responsive Hydrogels for Controlled Drug Delivery |
| Author(s) |
Parker M. Toews, Jeff Bates |
| On-Site Speaker (Planned) |
Parker M. Toews |
| Abstract Scope |
Hydrogels are biocompatible, stimuli-responsive materials which can be employed as drug delivery devices. Through this study, molecular imprinting is used to embed target molecules within the hydrogel matrix through hydrogen bonding. By changing the concentration of pH-sensitive monomer within the hydrogel mixture, it was demonstrated how an ideal concentration could be reached to minimize the response time whilst maximizing the drug delivery capability of the hydrogel. Through changes in the ionic concentration of the environment, it is demonstrated how a 2-hydroxyethyl methacrylate (HEMA) hydrogel responds to this, effectively releasing or absorbing drug based on these changes. QCM, UV-Vis-NIR, and FT-IR are used to supplement the swelling data collected to effectively develop a predictive model of drug release from these hydrogels. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Polymers, Characterization, Mechanical Properties |