| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Facile Green Synthesis of Dual Stabilized Near-Infrared CuInSe/ZnS Quantum Dots as Fluorescent Probes for Cancer-Bacteria Imaging |
| Author(s) |
Samuel Oluwatobi Oluwafemi |
| On-Site Speaker (Planned) |
Samuel Oluwatobi Oluwafemi |
| Abstract Scope |
Herein, we report the effect of dual stabilization in producing NIR fluorescent CuInSe/ZnS quantum dots (QDs) and their use as imaging probes in cancer-bacteria therapy. The as-synthesised NIR QDs were stabilized using different combinations of hydrophilic dual capping agents, MPA-Gelatine, TGA-Gelatine, MPA-Citrate and TGA-Citrate. The optical characteristics of the prepared dual-stabilized CuInSe/ZnS QDs indicate that the material has high stability and fluorescence quantum yield. The cytotoxicity evaluation showed that cells treated with dual stabilised CuInSe/ZnS QDs displayed good cell viability against malignant fibrous histiocytoma-like (KM-Luc/GFP) cells, mouse colon carcinoma (C26) cells and mouse mammary carcinoma (FM3A-Luc) cells. It also showed high affinity to prostate and human adenocarcinoma cells with no indication of QDs uptake by normal prostate cells. The biofilm analysis showed that the QDs uptake was elevated in Staphylococcus aureus (Gram-positive bacteria) than in Escherichia coli (Gram-negative bacteria). |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Nanotechnology |