| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
Functional Nanomaterials: Functional Low-Dimensional (0D, 1D, 2D) Materials 2022
|
| Presentation Title |
Engineered Nanoclays in Bone Tissue Engineering and Bone Metastasis of Cancer |
| Author(s) |
Kalpana S. Katti, Haneesh Jasuja, Dinesh R Katti |
| On-Site Speaker (Planned) |
Kalpana S. Katti |
| Abstract Scope |
Nanoclays are unique nanomaterial systems that are altered with small molecules called as ‘modifiers’ to result in ‘engineered nanoclays’ that are the primary components of polymer-clay-nanocomposites. These nanocomposites have a variety of applications as structural composites, diffusion barrier coatings and biomedical. We report a simulations-based design of novel polymer-clay-nanocomposites with varying modifier molecules especially suited for as scaffolds for bone tissue engineering. The complex hierarchical structure of the bone-mimetic collagen fibrils is created using the nanoclay platform. Besides the applications in regenerative medicine, we use these engineered bone structures as testbeds for evaluation of breast and prostate cancer bone metastasis. The novel metastatic cancer testbeds are used to screen novel drugs and develop new metastasis biomarkers such as nanomechanical, IR and RAMAN spectroscopic. Both the mechanical properties as well as biological response of human mesenchymal-stem-cells and human cancer cells is tailored and impacted with the use of engineered nanoclays. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Nanotechnology, Mechanical Properties |