| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Structure-Property Relationships in Molecular Crystal Deformation
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| Presentation Title |
Understanding milling behavior of pharmaceutical crystals through quasistatic and dynamic mechanical testing |
| Author(s) |
Soumyadeep Sen, Jamshid Ochilov, Peter Yip , Tianyi Xiang, Nick Seaton, Geoffrey Rojas, Suraj Ravindran, Changquan Calvin Sun, Nathan A Mara |
| On-Site Speaker (Planned) |
Soumyadeep Sen |
| Abstract Scope |
The pharmaceutical industry has been driven to understand and enhance milling efficiency of Active Pharmaceutical Ingredients (APIs) to improve accuracy of dosage, ease of fabrication and bioavailability. We aim to inform industrial-scale dry milling models by integrating insights from Nanoindentation and dynamic (Laser-Induced Particle Impact Test) mechanical testing of D-Mannitol. Employing this pair of mechanical characterization techniques across diverse strain rates to mimic milling conditions, this research aims to investigate the effects of mechanical properties (e.g. modulus, hardness, fracture toughness, fracture and plastic deformation energy). The post-indentation/ post-impact surface morphology (slip steps vs. fracture) is analyzed via Scanning Electron Microscopy (SEM), Confocal Microscopy, Atomic Force Microscopy (AFM), and X-ray Diffraction (XRD). Mechanical behavior will be discussed in terms of the energetic competition between plastic deformation and fracture, and its dependence upon crystal structure and chemistry. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Mechanical Properties, Characterization, |