| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
An Investigation on the Effect of Contrast Agents in the Chitosan-Nanoclay Shear Thinning Hydrogel for Trans-Catheter Arterial Embolization |
| Author(s) |
George Varghese P J, Peng Chen, Keren Zhao, Mitesha Saha, Jingjie Hu |
| On-Site Speaker (Planned) |
George Varghese P J |
| Abstract Scope |
Shear thinning hydrogels are emerging as a potential candidate of embolic agents for minimally invasive transcatheter arterial embolization. The transformation from solid to liquid and vice-versa on the application and removal of shear force enables the shear thinning hydrogels to successfully occlude vasculatures of any diameters and thus can be used for the treatment of diseased or injured vasculature. Imageability of the embolic gel is of paramount importance as for successful occlusion of vasculatures requires real time monitoring of the deployment of the embolic agents. Here, we studied the effect of different contrast agents, including iohexol, OmnipaqueTM and tantalum microparticles, on the radiopacity on an established chitosan – nanoclay hydrogel system. The gels exhibited exceptional contrast under x-ray imaging modality. In addition, the rheological behavior, injectability of the gel through a clinically relevant catheter, hemocompatibility and cell biocompatibility were not compromised, highlighting the hydrogel’s potential for transcatheter arterial embolization. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Mechanical Properties, Other |