| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Surface Modification of Plasmonic Nanoparticles by Aryl Diazonium Salts for Raman Bioimaging and Biosensing |
| Author(s) |
Da Li, Yang Zhang, Fan Sun, Nordin Felidj, Nathalie Gagey-Eilstein, Aazdine Lamouri, Philippe Nizard, Jean Pinson, Kelly Aubertin, Florence Gazeau, Claire Mangeney, Yun Luo |
| On-Site Speaker (Planned) |
Yun Luo |
| Abstract Scope |
Bioimaging uses imaging modalities to visualize biological processes. Fluorescent dye staining is widely used in biological research, but suffers from spectral overlap and photo-bleaching. Surface enhanced Raman spectroscopy (SERS) addresses these issues, offering improved imaging accuracy due to its narrow spectral peaks, light-stable reporters on metal surfaces, and nanoscale resolution (< 50nm). Our work explores aryl diazonium salts encoded gold and silver nanoparticles (AuNPs and AgNPs) as Raman imaging contrast agents. Unlike thiol-grafted NPs, aryl diazonium salts provide more stable nanocomposites due to robust covalent metal-C bonding. We prepared multilayer functionalized plasmonic NPs using three aryl diazonium salts as SERS tags for multiplex imaging tumor cells [1]. Additionally, aryl diazonium salts were used as coupling agents for dual probe sensing chips to detect glucose in artificial urine [2].
References.
[1] D. Li, et al, Nanoscale, 2022, 14, 1452.
[2] D. Li, et al. ACS Applied Bio Materials 2024, 7, 2254. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Surface Modification and Coatings, Nanotechnology, Biomaterials |