| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
Impact of Type 2 Diabetes on the Lacunar Canalicular Network in Cortical Bone: A Connectomic Analysis |
| Author(s) |
Claire Acevedo |
| On-Site Speaker (Planned) |
Claire Acevedo |
| Abstract Scope |
Type 2 diabetes is a global health issue with profound effects on various organ systems and tissues, including bones. Diabetes significantly compromises bone quality and mechanical properties, causing mineralization disturbances and increasing microdamage, leading to a higher fracture risk despite normal bone mineral density. Additionally, diabetes impacts osteocytes, key cells in maintaining skeletal homeostasis, by disrupting their lacunar-canalicular network (LCN). To investigate diabetes's impact on the LCN, we used confocal laser scanning microscopy and connectomic analysis to quantify the 3D LCN in cortical bones from Zucker Diabetic Sprague Dawley rats (diabetic rat model) and control Sprague Dawley rats. Our findings indicate that diabetes significantly reduces canalicular density (21%) and node density (30%) in the cortical bone's mid-cortex region but not near the endosteum. This study broaden our understanding of diabetes-related bone pathology and informs potential avenues for osteocyte-targeted therapies to mitigate diabetes's adverse effects on skeletal health. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Computational Materials Science & Engineering |