About this Abstract |
Meeting |
TMS Specialty Congress 2025
|
Symposium
|
The 7th International Congress on 3D Materials Science (3DMS 2025)
|
Presentation Title |
Drug Delivery from Nose to Brain with Three-Dimensionally (3D) Produced Microneedle:A New Approach to Migraine Treatment |
Author(s) |
Elif Zehra Atukeren, Songul Ulag |
On-Site Speaker (Planned) |
Elif Zehra Atukeren |
Abstract Scope |
Migraine is a type of headache on one side of the head because of abnormal brain activity. Among various drug use methods, intranasal drug use is significantly advantageous for rapid and accurate release of the drug. Microneedles is envisaged to improve the release of drugs into the brain by overcoming possible obstacles during drug absorption through the nose.
In this research, microneedles were produced by a DLP 3D printer. Gelatin methacryloyl was used to obtain microneedles, and salicylic acid was loaded to investigate the drug release behaviour from the needles. Morphological analysis was carried out using a scanning electron microscope. Fourier transform infrared spectrometer was used to investigate molecular structures. Mechanical properties were analyzed using a tensile testing device. In vitro drug release test was performed on microneedles via UV-Vis spectrophotometer. As a result, microneedles were produced enabling sustained drug release successfully from nose to brain. |
Proceedings Inclusion? |
Undecided |