| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Mucus-mimicking Selective-permeable Hydrogels |
| Author(s) |
Shaoting Lin |
| On-Site Speaker (Planned) |
Shaoting Lin |
| Abstract Scope |
Existing efforts on tailoring transport properties of hydrogels mainly rely on two approaches: filtering by size and filtering by permanent interaction, but neither can be readily adapted for differentiated transport control of biomolecules in body fluids. In the talk, I will share our recent efforts in developing selective-permeable hydrogels for independently modulating the transport of biomolecules. Inspired by selective-permeable mucus, we hypothesize that the synergy of network elasticity and reversible interaction in hydrogels independently modulates the transport of target and non-target biomolecules, thereby enabling their selective and enhanced transport. We further develop a molecular transport theory to construct a phase diagram, providing a theoretical guideline for the rational design of selective and enhanced transport of biomolecules in hydrogels. Guided by the phase diagram, we aim to design a hydrogel that enables selective and enhanced transport of carcinoembryonic antigen (CEA), a biomarker associated with the progress of colorectal cancer. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Polymers, Mechanical Properties, Biomaterials |