| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Influence of Nanoscale Hydration on the Micro-structural Properties of Human Cortical Bone |
| Author(s) |
Elizabeth Montagnino, Glynn Gallaway, Thomas Siegmund , John Howarter |
| On-Site Speaker (Planned) |
Elizabeth Montagnino |
| Abstract Scope |
Hydration at the nanostructural level of bone, a hierarchal composite material, has an essential role in fracture resistance. Bound water found within the collagen triple-helix increases the volume of the organic matrix while, water at the collagen-mineral interface transfers load between the phases, both having an influence of the overall fracture toughness. Small-angle x-ray and wide-angle x-ray scattering (SAXS/WAXS) was used to characterize D-spacing under tensile load for bone specimen with controlled degrees of internal hydration. To modulate the water in the organic matrix and at the collagen-mineral interface, human cortical bone samples were partially dehydrated and demineralized in controlled environments and then treated under pharmaceutical conditions to understand the ability of the organic matrix to hydrate and improve the mechanical response of the bone.
This work is supported by NSF Award 1952993 |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Mechanical Properties, Characterization |