| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
Exploring the Effects of Disease on Teeth: Mouse Models of Type 1 and Type 2 Diabetes |
| Author(s) |
Katherine L. Tang, Sophie Ceteznik, May Kim, Karin Bornfeldt, Jenny Kanter, Hai Zhang, Dwayne Arola |
| On-Site Speaker (Planned) |
Katherine L. Tang |
| Abstract Scope |
Dentin is a hierarchically structured hard tissue comprising most of the tooth by volume. Dentin plays an important role in resisting the cyclic loads involved in daily oral function, but embrittles with age due to increased mineral content and cross-linking of the organic matrix over time. However, little is known about other factors that may compromise the structural integrity of the hard tissue. This investigation characterized alterations to tooth dentin in mouse models of type 1 and type 2 diabetes. Compositionally, we found that both types of diabetes cause reductions in the mineral-to-organic ratios compared to non-diabetic littermates (p<0.05). Molars from diabetic mice were also noted to exhibit reductions in hardness (p<0.05). While microstructural changes were not noted, optical microscopy revealed significant wear of the molar crowns, which may reflect the compositional and mechanical degradation of the tissue in diabetic mice. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, Mechanical Properties |