| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
BioNano Interfaces and Engineering Applications
|
| Presentation Title |
Antiviral Surface Topographies on Metal Surfaces |
| Author(s) |
Terry C. Lowe, Rebecca A. Reiss, Heather S. Slomski |
| On-Site Speaker (Planned) |
Terry C. Lowe |
| Abstract Scope |
The surfaces of solid-state metals and alloy can have antimicrobial effects based on their ability to disrupt critical biochemical and sub-cellular microbe processes. The extent to which such disruptive effects can be enhanced by altering surface architectures is explored in this work for 99.9% copper surfaces. We fabricated microscale and nanoscale topographies on copper strip, wire, and particles and then evaluated their antiviral effects using the enveloped Phi6 virus, a common surrogate for Coronaviruses, Ebola, and Hantivirus. Surface features that enhance microbe adsorption, surface chemical activity, and surface charge distribution were designed and then created by aqueous and gaseous phase reactions. The geometric features were quantified to show the relationship between topography and the time required for virus deactivation. Times for 50% reduction of the Phi6 virus titers (T50) varied widely depending upon surface architecture and were as low as 18 seconds. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Copper / Nickel / Cobalt, Surface Modification and Coatings |