| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
Functional Nanomaterials: Functional Low-Dimensional (0D, 1D, 2D) Materials 2022
|
| Presentation Title |
Electrical Detection and Characterization of Individual Molecules with Single Nanometer-scale Pores |
| Author(s) |
John J. Kasianowicz, Jessica Benjamini, Kenneth Rubinson, Haiyan Wang |
| On-Site Speaker (Planned) |
John J. Kasianowicz |
| Abstract Scope |
Biological nanometer-scale protein pores are the basis of many critical functions, including nerve and muscle activity and the transport of macromolecules across cell membranes. We have been adapting them for a wide range of single molecule-based physical and analytical applications, including the detection, characterization, and identification of ions, synthetic polymers, DNA, metallic nanoparticles, and proteins in aqueous solution. In the absence of analyte, an ionic current of electrolytes flows through a single nanopore in response to an applied electrostatic potential. When an individual molecule enters a nanopore, both the degree by which it reduces the current and the residence time of the molecule in the nanopore depend on the molecule’s physical and chemical properties. The method has been used to sequence DNA, discriminate between polymers based on their size, and identify subtly different species of metallo-nanoparticles. The development of solid-state nanopores for single molecule detection applications will also be discussed. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Polymers, Nanotechnology |