| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Multi-scale Elemental, Structural and Mechanical Characterization of the Influence of Different Medicines on the de novo Mineralization of Zebrafish Caudal Fin |
| Author(s) |
Po-Yu Chen, Fabio Bohns, Yang-Rong Shih |
| On-Site Speaker (Planned) |
Fabio Bohns |
| Abstract Scope |
Osteoporosis is a degenerative bone disease defined by a reduction in mineral density and altered micro-architecture, resulting in brittle bones. The long-term administration of Prednisolone is known to induce osteoporosis in humans while the most common medicine used to reverse the process is Alendronate. Zebrafish has emerged as a model to osteoporosis screening due to its low cost and ability to regenerate its parts and organs. This work will aim on the influence of both drugs on the de novo mineralization of zebrafish caudal fin and the mechanical properties of the newly regenerated bones. The medicine will be administered to adult zebrafish for 28 days and morphometric analysis will be performed under stereomicroscope. Elemental and micro-structural analysis of fins will be evaluated by EPMA, Raman spectroscopy and SEM/EDS. Mechanical testing will be performed using PF-QNM and nanoindentation. The effect of various medicines on fin mineralization will be discussed. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |