| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Mechanics and Physiological Adaptation of Hard and Soft Biomaterials and Biological Tissues
|
| Presentation Title |
Development of novel mechanochemically active hydrogels |
| Author(s) |
Jamie J. Kruzic, Yuwan Huang, Alaa Ajam, Zihao Li, P. Bhakthi Jayathilaka, Md Shariful Islam, Chavinya Ranaweera, Meredith Silberstein, Kristopher Kilian |
| On-Site Speaker (Planned) |
Jamie J. Kruzic |
| Abstract Scope |
Inspired by how forces in biological tissues guide their functions in-vivo, we have developed bioinspired hydrogels where an applied force facilitates molecular changes that include: i) molecule immobilization from the surrounding environment, ii) molecule release into the environment, or iii) internal reactions between different mechanophores to change the hydrogel properties. We have incorporated these mechanochemistry concepts into covalently bonded poly(ethylene glycol) and polyacrylamide hydrogels. We have further explored the reinforcement of our mechanochemically active networks with ionically bonded alginate networks to create tough and stretchable double network hydrogels. This presentation will report on the mechanical and functional properties of our mechanochemically active hydrogels. Examples will be shown regarding how the magnitude of the mechanical forces/strains can be used to modulate the functional response and how reinforcement to form a stretchable double network hydrogels presents challenges for maintaining the mechanochemical functionality. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Polymers, Mechanical Properties |