| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
A Novel Polymethylmethacrylate Silicon Nitride Bone Cement |
| Author(s) |
Elia Marin, Qing Yang, Obinna M. Ajunwa, Enrico Marsili, Bryan J. McEntire, Guiseppe Pezzotti |
| On-Site Speaker (Planned) |
Bryan J. McEntire |
| Abstract Scope |
Prior research demonstrates that monolithic silicon nitride (Si3N4) enhances the healing of soft and osseous tissue while concurrently lysing bacteria, viruses, and fungi. In an aqueous environment, silicon and nitrogen are eluted from its surface and converted to silicic acid (Si(OH)4), ammonium (NH4OH), and ammonia (NH3). These moieties are locally responsible for Si3N4’s favorable human biology. More recent studies have shown that these same benefits can be extended to a commonly used bone cement – polymethylmethacrylate (PMMA). Forming composites of PMMA with minor fractions of Si3N4 particles (5 to 15 wt.%) has proven to be effective in promoting osteogenesis and preventing infections without compromising the polymer’s bulk properties. The range of compositions, processing, properties, and biological efficacy of these unique composites will be reviewed and discussed. Clinical use of PMMA/Si3N4 composites could be an important new step in improving patient outcomes for various craniomaxillofacial, dental, arthroplasty, and trauma procedures. |