| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
Functional Nanomaterials: Functional Low-Dimensional (0D, 1D, 2D) Materials 2022
|
| Presentation Title |
Rapid and Scalable Fabrication of Hierarchical Multiscale Nanocomposite Films for Bone Tissue Repair and Infection Control |
| Author(s) |
Amanda Clifford |
| On-Site Speaker (Planned) |
Amanda Clifford |
| Abstract Scope |
To increase the lifespan of metallic implants for skeletal tissue repair, both surface chemistry and morphology can be modified to prevent post-operative infection and enhance bone tissue integration at the interface. However, surface modification strategies used to fabricate coatings that simultaneously address the aforementioned requirements often utilize complicated fabrication processes, which are difficult to scale. In this talk, I will describe development of a new electrochemical process for rapid and scalable fabrication of nanocomposite films with programmed surface chemistry and hierarchical multiscale topography, which we predicted would enhance the longevity of orthopaedic implants. Surface modification utilizing these functional nanofilms resulted in increased osteoblast adhesion, proliferation, and resistance to bacterial biofilm formation compared to uncoated metallic substrates. Finally, we translated this technique for surface modification of high-touch surfaces in clinical settings, using an alternative nanofilm that prevented transmission of infectious disease by hindering adhesion and proliferation of bacteria cells while concurrently acting as biocidal agent towards a wide range of pathogens. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nanotechnology, Thin Films and Interfaces, Biomaterials |