| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
2025 Technical Division Student Poster Contest
|
| Presentation Title |
SPG-94: A Quasi-Brittle Fracture Mechanics Model for Assessing Treatment Effects in Human Cortical Bone |
| Author(s) |
Glynn Gallaway, Thomas Siegmund |
| On-Site Speaker (Planned) |
Glynn Gallaway |
| Abstract Scope |
To better understand fragility fractures, there is a need to investigate bone fracture mechanics. FDA-approved compound Raloxifene provides a testbed to study fracture in the context of bone quality treatments. We hypothesize that quasi-brittle fracture mechanics (QBFM) can assess treatment changes in the fracture properties of bone. Cadaveric human femur tissue is sectioned into notched prismatic bars and treated with a Raloxifene (RAL) or control (VEH) solution. Four-point bend fracture experiments are conducted with 3D X-ray. FPZ size is measured directly from images. Quasi-brittle fracture mechanics methods are used to obtain intrinsic material properties. RAL treatment is found to significantly increase the FPZ size compared to VEH. Intrinsic fracture toughness for RAL is found to be 36% higher than that for VEH, while in intrinsic length scale for fracture for RAL is 86% higher than for VEH. QBFM analysis of bone is necessary to understand treatment effects across length scales. |
| Proceedings Inclusion? |
Undecided |
| Keywords |
Biomaterials, Mechanical Properties, Other |