| About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
3D Printing of Biomaterials and Devices
|
| Presentation Title |
C-1: Surface Treatment of Titanium for Bone Tissue Engineering and Drug Delivery Applications |
| Author(s) |
Farid Ahmadpour Esmaeilabadi, Prantik Chowdhury, Paige Bothwell, Sahar Vahabzadeh |
| On-Site Speaker (Planned) |
Farid Ahmadpour Esmaeilabadi |
| Abstract Scope |
Titanium and its alloys are the most common metals for hard tissue engineering applications. However, implant loosening results in failure which demands revision surgeries. In current work, we have used combination of surface modification and incorporation of drugs/biomolecules to evaluate the cellular response. Our results show that anodization creates a uniform nanotubular structure, that allows sustained release of aloe emodin at both pH of 7.4 and 5.0. Incorporation of aloe emodin as an anti-cancer drug does not have any significant effect on osteosarcoma; however, enhances the osteoblast cell proliferation, significantly. In the second route, alkali treatment forms a random but uniform web-like microstructure. Incorporation of the natural biomolecule of interest allows the attachment and proliferation of the osteoblast cells through controlled release of the biomolecule. These show that both surface modification techniques are suitable for drug delivery, and cellular response highly depends on the composition of the drug/biomolecule of interest. |