| About this Abstract |
| Meeting |
MS&T23: Materials Science & Technology
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Synthesis and Characterization of Nanofibrous Chitosan/Hydroxyapatite Microspheres |
| Author(s) |
Song Chen, Akiyoshi Osaka |
| On-Site Speaker (Planned) |
Akiyoshi Osaka |
| Abstract Scope |
Biopolymer/hydroxyapatite composites are one type of the most promising bone regenerative materials because of their excellent biocompatibility and strong osteoconductivity. In this study, we hydrothermally treated the microspheres of Ch-HAp NPs under acidic conditions, and successfully synthesized novel Ch-HAp microspheres that had a hierarchical microstructure, i.e., chitosan (Ch)-hydroxyapatite (HAp) nanoparticles in the core and HAp nanowires (HAP NWs) on their surface. The HAp microspheres retained the size of the original Ch-HAp microspheres, ~200 µm in diameter, and the NWs were ~10µm long and 100 nm in diameter. Thus the surface morphology looked like that of urchin. Acidic autoclaving was essential for the in situ transformation of the Ch-HAp NPs to the Ch-HAp NWs. The MTT assay and MC3T3-E1 cells culture indicated that both microspheres of Ch-HAp and Ch-HAp NPs-HAp NWs were biocompatible and supported cell attachment and proliferation. Hence, they had a potential as biocompatible cell carrier. |