| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
BioNano Interfaces and Engineering Applications
|
| Presentation Title |
Grain Size Effects and Mechanisms for Increased Antimicrobial Efficiency in Ultrafine-grained Bulk Copper |
| Author(s) |
Evander Ramos, Isabella Bagdasarian, Yaqiong Li, Masuda Takahiro, Yoichi Takizawa, Justin Chartron, Alex Greaney, Zenji Horita, Joshua Morgan, Suveen N. Mathaudhu |
| On-Site Speaker (Planned) |
Suveen N. Mathaudhu |
| Abstract Scope |
Copper and it’s alloys have long been known for their antiviral and antibacterial properties, and in the course of the global pandemic, research on ways to accelerate their effectiveness have come to the forefront. Recent studies have reported that when the crystal size of bulk copper reduces towards the nanoscale, the anti-viral and anti-microbial efficiency increases non-linearly. The mechanisms for this are diverse, and include the increase in volume fraction of ionic pathways to the surface, oxidation-reduction, topological features and others. In this study, we investigate the antibacterial characteristics of nanocrystalline pure copper produced by severe plastic deformation (SPD), and based on a literature review and our own emerging data, attempt to unravel the mechanisms that promote bacteria or cell destruction as a function of grain size. The versatility of SPD methods allows for the fabrication of bulk components that, unlike thin-film coating approaches, may enable scalability of medical applications. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nanotechnology, Copper / Nickel / Cobalt, Biomaterials |