| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advances in Biomaterials for 3D Printing of Scaffolds and Tissues
|
| Presentation Title |
Effects of Topographic Parameters on a Micropillar Surface on Cell Migration and Morphology |
| Author(s) |
Srikumar Krishnamoorthy , Jiachen Liu, Heqi Xu, Zhengyi Zhang, Changxue Xu, Md Shahriar |
| On-Site Speaker (Planned) |
Jiachen Liu |
| Abstract Scope |
Guided cell migration refers to the engineering of local cell environment to specifically direct cell migration, and has important applications such as utilization in cell sorting and wound healing assays. Graded micropillar surfaces have been utilized for achieving guided cell migration. Topographic parameters such as micropillar diameter and spacing gradient may have effects on the morphology of attached cells. It is critical to understand this interaction between the cells and the underlying microscale structures. In this study, a graded micropillar substrate has been fabricated to investigate the effects of the microtopography on the cell morphology in terms of the cell aspect ratio and cell circularity. The results regarding interaction between the living cells and the underlying microscale topographic surfaces benefits better understanding of the formation and regeneration of tissues and organs. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Additive Manufacturing, Polymers |