| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
B-14: Biodegradable 3D Fibrous Scaffold with Co-axially Aligned Carbon Nanotubes for Directional Regeneration of Peripheral Nerves |
| Author(s) |
Souvik Ghosh, Swati Haldar, Sumeet Gupta, Ankita Bisth, Samrat Chauhan, Partha Roy, Debrupa Lahiri |
| On-Site Speaker (Planned) |
Souvik Ghosh |
| Abstract Scope |
Connecting nerve sprouts and Büngner bands arising respectively, from the anterior and distal ends of a nerve gap is critical for its bridging. However, inefficient reconnection between nerve sprouts and Büngner bands causes incomplete axonal regeneration. Nerve conduits partially alleviate this situation. Electrical impulses stimulate directional growth of nerves. But provision for electrical cues is absent in available conduits. Design, fabrication, characterization and functional validation of a novel biodegradable conductive electrospun scaffold with nanfibers co-axially re-inforced with MWCNTs is described here. Anisotropic conductivity in the scaffold is provided by aligning the reinforced nanofibers while spinning. The scaffold could regenerate injured rat nerve completely and restored lost motor function to the injured limb. The electrical conductivity of the scaffold facilitated Wallerian degeneration and guided of nerve sprouts towards the freshly formed Büngner bands. Therefore, the reported scaffold is a peerless recourse among neural regenerative templates known thus far. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |