| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Freeze-cast Ceramic Membranes for Pathogen Capture and Bio-processing |
| Author(s) |
Katherine T. Faber, Orland Bateman, Noriaki Arai, Laura Quinn, Julia Kornfield, Mamadou Diallo |
| On-Site Speaker (Planned) |
Katherine T. Faber |
| Abstract Scope |
Pores have long been regarded as unwelcome in the quest for the perfect ceramic. The deleterious role of pores on mechanical properties notwithstanding, porosity is now critical in expanding the utility of ceramics in bio-related applications. Here we describe freeze casting, a ceramic processing method, which can result in directionally aligned pores with tailorable size and morphology. These are controlled by freezing front velocity, temperature gradient, solvent, solute/particle concentration, and coarsening. Two examples of freeze-cast membranes for biomedical applications are conceived using polysiloxane, which upon casting and pyrolysis, produces silicon oxycarbide. The first is a dendritic pore blood analysis platform, in which thousands of independent dendritic pores, each possessing an array of hundreds of secondary dendrite arms for pathogen capture at zeptomolar concentrations. The second relies on functionalized cellular pores, filled with a functional microgel in a polymer matrix, and designed as selective adsorbers for biopharmaceutical manufacturing. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Ceramics, Solidification, Other |