| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Biomimetic Design of Antibacterial Chimeric Peptides: Engineered Peptides for Next-Generation Dental Restorations |
| Author(s) |
Nur Ceren Kabakci, Aya Kirahm Cloyd, Kyle Boone, Paulette Spencer, Candan Tamerler |
| On-Site Speaker (Planned) |
Nur Ceren Kabakci |
| Abstract Scope |
The persistent issue of oral health, particularly with composite restorations, demands urgent attention. The challenge lies in the complex adhesive-dentin interface, where the irregular infiltration of resin monomers into the demineralized dentin matrix and a compromised collagen network creates a hot-spot for bacterial colonization, leading to recurrent dental caries. This problem at the dentin-adhesive interface requires innovative bioactive and biohybrid solutions.
Our group has pioneered the development of multi-functional chimeric peptides through advanced combinatorial and computational methods. We engineered a chimeric peptide by integrating a collagen-binding domain with an antimicrobial domain by spacer design. This design was furthered employing a dynamic collagen self-assembly platform, designed to mimic the complexity of the dentin extracellular matrix. This platform enables a thorough evaluation of the binding efficiency and antimicrobial potency of our peptides. Our findings promise advancements in dental materials, enhancing the longevity and effectiveness of restorations by addressing the dentin-adhesive interface interactions. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Thin Films and Interfaces, Machine Learning, Other |