| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advances in Biomaterials for Bioink Formulation and 3D Printing of Scaffolds
|
| Presentation Title |
Enhanced mechanical properties of 3D printed gelatin methacryloyl (GelMA)-based hydrogels for peripheral nerve recovery |
| Author(s) |
Yerim Lee, Jaewon Kim, Prabir Patra, Jahyun Koo |
| On-Site Speaker (Planned) |
Yerim Lee |
| Abstract Scope |
Peripheral nerve injury (PNI) represents a common clinical challenge. Due to the inappropriate dispersion of regenerating axons, developing nerve guidance conduits (NGCs) as autologous nerve graft replacements for repairing long-distance nerve defects remains a challenge. Bio-inspired NGCs with multifunctional properties have been proposed as an alternative to single hollow lumen NGCs. However, limited mechanical properties hinder their use in high-resolution DLP 3D printing. In this study, the mechanical properties of Gelatin methacryloyl (GelMA)-based hydrogel were improved by incorporating polyvinyl alcohol (PVA). The enhanced mechanical properties enabled high-resolution printing of the hydrogel, making it possible to fabricate micro-sized channels that closely resemble actual nerve fascicles. GelMA and PVA are also biodegradable, allowing the NGCs fabricated using these materials to overcome limitations such as nerve compression. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Additive Manufacturing, Polymers |