| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Society for Biomaterials: Biological Response to Materials and Material’s Response to Biological Environments
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| Presentation Title |
C-8: Osteoblast Cell Interaction with Iron-deposited Titanium for Orthopedic Applications
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| Author(s) |
Dexter Kling, Paige Bothwell, Sahar Vahabzadeh |
| On-Site Speaker (Planned) |
Dexter Kling |
| Abstract Scope |
Surface modification of titanium (Ti) and its alloys is a common method to improve bone tissue formation and integration for orthopedic and craniomaxillofacial applications. In current work, we used combination of alkali-treatment and physical vapor deposition to roughen the surface and deposit iron (Fe) on the surface of titanium at different thicknesses. Fe plays an important role in bone metabolism and remodeling, and is believed to enhance osteogenesis. The optimized thicknesses of 150 Å and 500 Å were selected for biological characterization. We found that alkali-treatment using 10 M NaOH medium increases the surface roughness of Ti, significantly. Further modification by Fe deposition did not alter the network structure obtained by alkali-treatment and Fe was uniformly distributed on the surface. Our results also showed that alkali-treatment enhances the VEGF expression in Ti. Both alkali-treatment and Fe deposition change the osteoblast cell proliferation and differentiation, which depends on Fe concentration. |