| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
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Materials Science for Global Development -- Health, Energy, and Environment: An SMD Symposium in Honor of Wole Soboyejo
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| Presentation Title |
Engineering Functional Bone Constructs for Repairing Non-union Bone Defects |
| Author(s) |
Ali Salifu, John Obayemi, Vanessa Uzonwanne, Precious Etinosa, Chukwudalu Nwazojie, Joshua Gershlak, Glenn Gaudette, Wole Soboyejo |
| On-Site Speaker (Planned) |
Ali Salifu |
| Abstract Scope |
Tissue-engineered bone substitutes are emerging as potential alternatives to conventional bone grafts for bone repair due to the latter's limitations. This talk presents two strategies to engineer functional bone tissues. First, the mechanical stimulation of RGD-functionalized polycaprolactone/hydroxyapatite scaffolds seeded with human fetal osteoblast (hFOB) cells in a perfusion bioreactor for 21 days is shown to enhance in vitro osteogenesis (ECM production and mineralization) and the mechanical properties of the engineered bone constructs. The second part presents decellularized lucky bamboo scaffolds as economical, "green," and scalable alternatives for complex bone scaffold development. RGD-functionalized decellularized bamboo scaffolds are shown to promote hFOB cell proliferation and in vitro and in vivo bone regeneration. The degradation of the decellularized scaffolds is also engineered using injectable cellulase-encapsulated poly(lactic-co-glycolic acid) microspheres and monitoring weight loss and compressive strength over 6 months. Our findings have implications for developing tissue-engineered bone constructs for repairing non-union bone defects. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Mechanical Properties, Polymers |