| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Seaborg Institutes: Emerging Topics in Actinide Materials and Science
|
| Presentation Title |
Advancing Actinium-225 Coordination Chemistry and Chelator Development for Targeted Alpha Therapy |
| Author(s) |
Megan Simms, Caroline Lara, Alex Ivanov, Nikki Thiele |
| On-Site Speaker (Planned) |
Nikki Thiele |
| Abstract Scope |
Actinium-225 is under intense investigation for use in targeted alpha therapy, a rising cancer treatment strategy that couples the cytotoxicity of alpha particles with the tumor specificity of biological targeting vectors to selectively eradicate cancer cells. To successfully harness Ac-225 for this application, the Ac ion must be stably bound to the targeted construct via a bifunctional chelator to prevent its redistribution to healthy tissues in vivo and subsequent off-target radiotoxicity. In support of the development of more effective chelators for Ac-225, we present our efforts to advance the fundamental coordination chemistry of the Ac(III) ion. Specifically, we describe the experimental determination of thermodynamic stability constants of Ac-225 complexes with a series of chelators relevant to targeted alpha therapy. Furthermore, we discuss how these data can be leveraged to guide future ligand design efforts for this underexplored radioactive ion, and present new chelation platforms developed in our lab to date. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nuclear Materials, Other, |