| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
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| Symposium
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Materials Science for Global Development -- Health, Energy, and Environment: An SMD Symposium in Honor of Wole Soboyejo
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| Presentation Title |
Targeted Theranostic Nanoparticles and Drugs Systems for The Detection and Treatment of Triple Negative Breast Cancer |
| Author(s) |
John Obayemi, Ali A. Salifu, Jingjie Hu, Vanessa O. Uzonwanne, Winston O. Soboyejo |
| On-Site Speaker (Planned) |
John Obayemi |
| Abstract Scope |
This work presents our recent efforts in the development of ligand conjugated nanoparticles and drug systems for the diagnosis and treatment of triple negative breast cancer (TNBC). Luteinizing Hormone Releasing Hormone, a ligand whose receptors are overexpressed on the surfaces of TNBC were conjugated to magnetite nanoparticles/cancer drugs. Under in vitro conditions, the specificity of the magnetite nanoparticles and targeted drug systems were explore using a combination of immunofluorescence staining and adhesion studies. The specificity was validated by in vivo studies complimented with ex vivo studies using a 5-week-old athymic female nude mice with induced subcutaneous xenograft breast tumors. Our in vivo results showed the enrichment of MRI nanoparticles contrast on the tumor 24-hours after tail-vein injection while the injected drug systems eliminated early and shrunk late-stage tumors. The implications of the findings are impactful for the development of ligand-conjugated nanoparticles/drug systems in the specific targeting and treatment of TNBC. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nanotechnology, Characterization, Biomaterials |