| About this Abstract |
| Meeting |
2023 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Effect of Collagen Molecular Damage at the Nanoscale on Different Hierarchical Levels |
| Author(s) |
Claire Acevedo, Michael Sieverts, Yoshihiro Obata, Dula Parkinson, Daan Pelt |
| On-Site Speaker (Planned) |
Claire Acevedo |
| Abstract Scope |
Visualizing bone's hierarchical structure at the microscale provides insight into the mechanism that allows the bone to resist fracture. High-resolution imaging at the micro-scale level is enabled by the synchrotron radiation micro-computed tomography (SRuCT) imaging at synchrotron light sources. Therefore, SRuCT can reveal the crack path and the extrinsic toughness mechanisms of a fractured bone sample and its interaction with bone microstructural features (e.g., canal, osteocyte lacunae). This research has been interrogating whether changes in microscale toughening mechanisms might take their origins from collagen damage at the molecular and nanoscale. This hypothesis was tested using a heat-treatment fragility model and by developing a novel method combining SRuCT and convolutional neural network to image in situ tissue deformation and crack growth. We found that collagen damage at the nanoscale adversely affects bone's toughening mechanisms by reducing amounts of crack deflection at the microscale and ultimately decreases the overall toughness of bone. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Characterization, |