| About this Abstract |
| Meeting |
MS&T22: Materials Science & Technology
|
| Symposium
|
Nanotechnology for Energy, Environment, Electronics, Healthcare and Industry
|
| Presentation Title |
H-13: Impedimetric Determination of Cortisol Using Gold Nanoparticles Functionalized Laser Induced Graphene Electrode |
| Author(s) |
Kyle C. Duke, Jose Gonzalez-Garcia, Jennah Markovitch, Kyle Preusser, Victoria Messuri, Anthony Romeo, Bhargavi Mummareddy, Pedro Cortes, Byung-Wook Park |
| On-Site Speaker (Planned) |
Kyle C. Duke |
| Abstract Scope |
Wearable biosensors have received a lot of attention for their promising applications in personalized medicine. Cortisol is a biomarker for various diseases and plays an important role in metabolism, blood pressure regulation, and glucose levels. This study is to create a flexible, wearable biosensor to detect cortisol in bodily fluid through contact with the skin. A direct laser writing technique was used to produce laser-induced graphene (LIG). The LIG was modified with gold nanoparticles to enhance impedance response. For non-invasive extraction of biomarkers, a hydrogel layer was incorporated onto the electrode surface. A cortisol antibody was immobilized through the surface chemistry. Cyclic voltammetry and electrochemical impedance spectroscopy were used to characterize the electrode and perform detection of cortisol. The characterizations were carried out in terms of detection limit, selectivity, sensitivity, and response time. Using 3D printed wristbands and wireless communication devices, it may be possible to monitor personnel in real-time. |