| About this Abstract |
| Meeting |
MS&T24: Materials Science & Technology
|
| Symposium
|
3D Printing of Biomaterials and Devices
|
| Presentation Title |
Phenolic-Loaded Scaffolds for Breast and Prostate Cancer Bone Metastasis Therapeutics |
| Author(s) |
Kalpana S. Katti, Preetham Ravi, Kalidas Shetty, Dinesh Katti |
| On-Site Speaker (Planned) |
Kalpana S. Katti |
| Abstract Scope |
Bone-metastasis of breast and prostate cancer results in poor prognosis. The arrival of cancer to bone renders the cancer highly drug-resistant, making the metastasized tumors spread prolifically, resulting in ultimate death. We have developed a 3D-printed mold-assisted freeze-extraction nanoclay scaffold as a testbed for bone metastasis. Although some of these extracts show anti-cancer efficacy in 2D, their efficacy towards bone metastasis is unknown. We evaluated the cytotoxicity of three plant extracts against bone metastasis. Computational studies are conducted on 30+ cancer proteins' affinity with the extracts’ phenolic compounds. All three plant extracts reduce cell viability in bone-metastasized cancer. Activation of the proapoptotic marker p53 is observed at bone metastasis. Further, the bone-metastatic cultures show high expression of anti-apoptotic marker bcl-2. Additionally, none of the plant extracts induce cytotoxicity in healthy bone cells. These studies indicate the potential for phytochemically enriched plant extracts as new therapeutics for bone metastasis. |