| About this Abstract |
| Meeting |
2021 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Cancer Testbed for Breast and Prostate Cancer Bone Metastasis |
| Author(s) |
Kalpana S. Katti, Haneesh Jasuja, Sumanta Kar, Dinesh R Katti |
| On-Site Speaker (Planned) |
Kalpana S. Katti |
| Abstract Scope |
Worldwide about 3.4M cases of breast and prostate cancer are reported each year resulting in about a million deaths. More than 90% of deaths are attributed to metastasis, the process of relocation of cancer to a remote site which is bone for the two cancers. We have developed biomimetic in vitro bone using nanoclay scaffolds using a specially designed bioreactor and have used this bone scaffold to generate human bone metastatic breast and prostate cancer tumors. The novel metastatic cancer testbed is used to screen novel drugs and develop new biomarkers of metastasis for which both commercial and patient derived cell lines are used. Novel nanomechanical, IR and RAMAN spectroscopic markers for progression of metastasis are also developed. We also report role of cancer cells on the osteogenesis of bone which has important ramifications on the bone stabilizing therapies that are often administered to bone metastasis patients. |
| Proceedings Inclusion? |
Planned: |