| About this Abstract |
| Meeting |
Materials Science & Technology 2020
|
| Symposium
|
Next Generation Biomaterials
|
| Presentation Title |
Biomimetic Patterns of Metallic Nanoparticles for Antimicrobial Applications |
| Author(s) |
Srikanthan Ramesh, Chaitanya Mahajan, Iris Rivero, Denis Cormier |
| On-Site Speaker (Planned) |
Srikanthan Ramesh |
| Abstract Scope |
Biomimetic patterns such as the ones found in sharkskin, insect wings, and crab carapace, by virtue of their roughness and shape discourage bacterial growth. Biomimicry has been used to prevent bacterial attachment in marine applications but their translation to tissue-engineered substrates has been limited due to the thermal and chemical sensitivity of biomaterials. We validate a scalable process consisting of aerosol jetting followed by photonic sintering allowing the patterning of biocompatible substrates. As a first step, shark fin-like structures have been created on polycaprolactone using silver and copper nanoparticles to study their antibacterial efficacy against Staphylococcus aureus and Escherichia coli. Our results suggest that the proposed approach allows the patterning and sintering of nanoparticles on substrates without damaging the thermoplastic substrates. Topographical analysis and the accuracy of deposition were analyzed using microscopy and profilometry. Bacterial studies indicate that the patterned substrates are effective against resisting bacterial growth responsible for osteomyelitis. |