Abstract Scope |
On-demand’ biomimetic tissue constructs should be the next revolution in healthcare science. Fully interconnected and biomimetically organised microvasculated 3D constructs have high demand to treat several bone-related diseases like osteoporosis, skeletal segment defects, limb salvage, accidental or tumoral bone loss, craniomaxillofacial disorder etc. Zirconia binderjetting (ZBJ) and zirconia paste printing (ZP2, a robocasting approach) are two of the most promising patient-specific bone tissue engineering technologies, where a range of bioceramic as well as metallic biomaterials can be used to develop design/anatomy-specific tissue constructs. Human bone mimicking mechanical properties, biomedically relevant surface roughness and highly interconnected porosity are the clinically relevant features ingrained in the custom developed scaffolds. Finite element analysis of the binderjetting and ZP2 printed scaffolds using realistic materials properties (derived from experimental approach), manufacturing and testing conditions can effectively predict the strength properties, while weakest link fracture statistics indicates the strength reliabilities of the microporous architectures. |