| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Bio-Nano Interfaces and Engineering Applications
|
| Presentation Title |
Tunable, Light-Actuated Silk Fibroin Composites for Biodevices at Biointerfaces |
| Author(s) |
Anne Katherine Brooks, Vamsi K. Yadavalli |
| On-Site Speaker (Planned) |
Vamsi K. Yadavalli |
| Abstract Scope |
While nature-derived materials offer inherent biocompatibility and biodegradability, they have contrasting properties that limit their use for applications at biointerfaces. Silk fibroin is mechanically strong, but lacks processability and adhesive domains. It lacks durability for dry processing in biointegrated electronics. We demonstrate tunable photocrosslinkable fibroin-gelatin composites (photofibrogel) with tunable properties for precise macroscale and microscale patterning. The composites are biocompatible and can be modified with electrically conductive micropatterns for cell guidance and stimulation. Viability of C2C12 myoblasts and indicators of maturation were measured using fluorescent microscopy. In addition, we show elastomeric silk fibroin via a composite with a polydimethylsiloxane that is optically transparent and shelf-stable over 6 months.
Such optimized composites are formed with reduced swelling and improved mechanical properties that enables further processing to include patterning features in 2 and 3 dimensions. Films support cell culture and can be used to deliver electrical stimulation for devices at biointerfaces. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Composites, Thin Films and Interfaces |