| About this Abstract |
| Meeting |
2021 TMS Annual Meeting & Exhibition
|
| Symposium
|
Advanced Functional and Structural Thin Films and Coatings
|
| Presentation Title |
Silicone Breast Implants: Grafting of a Bioactive Polymer to Improve the Bio-integration |
| Author(s) |
Mylan Lam, Vivien Moris, Vincent Humblot, Véronique Migonney, Céline Falentin-Daudré |
| On-Site Speaker (Planned) |
Mylan Lam |
| Abstract Scope |
Lately, the emergence of breast implants associated anaplasic large cell lymphoma (BIA-ALCL) has led to the reconsideration of breast implants safety. Characterized by a tightened capsular contracture, it causes pathological fibrosis and skin deformations which require the removal of the implant. The origins of BIA-ALCL remain unknown but bacterial infections appear as the main explanation. The surface’s non-wettability contributes to poor cell adhesion and non-specific protein adsorption. The presence of methyl groups makes the surface chemical modifications challenging.
Recently, our team has developed a simple way to graft a hydrophilic and bioactive polymer bearing sulfonate groups on silicone surfaces only by using UV. Characterization of the grafting was done by using colorimetric analysis, contact angle measurements, XPS, and AFM. Biologically, the polymer has already shown anti-bacterial properties with an anti-adhesive action on titanium surfaces and polymers for orthopedic applications. The same studies are currently under investigation on breast implants surfaces. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Surface Modification and Coatings, Polymers |