| About this Abstract |
| Meeting |
2025 TMS Annual Meeting & Exhibition
|
| Symposium
|
Nano and Micro Additive Manufacturing
|
| Presentation Title |
3-dimensional electrocatalytic on-site oxygenation using aerosol jet printing for implanted cell therapies |
| Author(s) |
Aaditya Nandakumar, Rahul Panat, Itzhaq Cohen-Karni, Chunshan Hu, Inkyu Lee, Seonghan Jo, Suyeon Kim |
| On-Site Speaker (Planned) |
Aaditya Nandakumar |
| Abstract Scope |
Implantable cell-based therapies are limited by the scarcity of oxygen owing to the lack of vascularization in the host. Previous methods of supporting implanted cells include oxygen evolution via decomposition of peroxides or circulating oxygen-encapsulating nanoparticles through the bloodstream, which suffer from limited oxygen supply and limited target oxygen delivery. Additionally, the poor diffusivity of oxygen decreases cell viability away from the source. Long-term oxygenation of cells in a 3D volume has eluded cell therapy devices. Electrocatalytic on site oxygenation has demonstrated sustained cell function with an unlimited oxygen supply. Here we show a 3D printed electrocatalytic device for implanted cell therapies, fabricated using aerosol jet printing (AJP).
AJP is an additive manufacturing technique capable of fabricating 3D structures using a variety of materials. Incorporating iridium oxide into these inks allows the creation of devices exhibiting greater sustenance of cell function for a variety of cell-based therapies. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Additive Manufacturing, Biomaterials, Nanotechnology |