| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
|
| Symposium
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Materials Science for Global Development -- Health, Energy, and Environment: An SMD Symposium in Honor of Wole Soboyejo
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| Presentation Title |
An Assessment of the Near-infrared Photothermal Effects of Honey-mediated Au Nanoparticles for Cancer Treatment via Experiments and Models |
| Author(s) |
Kwabena Kan-Dapaah |
| On-Site Speaker (Planned) |
Kwabena Kan-Dapaah |
| Abstract Scope |
Gold nanoparticles synthesized with honey (HM-AuNPs) have desirable features that make them ideal candidates for nanoparticle-assisted photothermal therapy (NA-PTT). However, their photothermal properties have not been previously explored. In this study, we assessed the photothermal properties of the HM-AuNPs under Near-InfraRed (NIR) laser irradiation. We characterised the optical and structural properties of spherical HM-AuNPs, which were synthesised via a chemical reduction method. Then, we performed photothermal measurements in 3 different media: aqueous solution, cell suspensions and agarose gel. Finally, we predicted the temperature and thermal damage profiles of HM-AuNP-filled superficial tumors embedded within normal breast tissue using a Finite Element Method (FEM). Experimental results showed that HM-AuNPs achieved photothermal efficiency of up to 40%, had an average absorption cross-section of (2.15±0.08) × 10-15 m2 and reduced cell viability of MDA-MB-468. Also, complete thermal damage of superficial tumors was predicted. Collectively, the results demonstrate the feasibility of using HM-AuNPs for NA-PTT. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Nanotechnology, Biomaterials, Other |