| About this Abstract |
| Meeting |
2024 TMS Annual Meeting & Exhibition
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| Symposium
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Materials Science for Global Development -- Health, Energy, and Environment: An SMD Symposium in Honor of Wole Soboyejo
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| Presentation Title |
Effects of RGD Functionalization and Host Immune Response on the Quality of Tissue-engineered Bone for Dental Applications |
| Author(s) |
Precious Etinosa, Ali Salifu, Sarah Osafo, John Obayemi, Vanessa Uzonwanne, Winston Soboyejo |
| On-Site Speaker (Planned) |
Precious Etinosa |
| Abstract Scope |
This work explores the combined effects of RGD functionalization and host immune response on bone regeneration. Polycaprolactone/hydroxyapatite scaffolds functionalized with RGD-C (arginine-glycine-aspartate-cysteine) peptides are implanted subcutaneously into immunocompromised (nude) and immunocompetent (C57) mice for 12 weeks. The quality of the regenerated bone in both mice models is assessed via histological studies (H & E, alizarin red S, and trichrome staining) and mechanical testing under compression. The ability of the engineered bone to support dental implants is also investigated by inserting dental screws and measuring the interfacial mechanical properties through screw push-out tests and finite element analysis. RGD functionalization only promotes bone regeneration within 2 weeks of implantation. However, the interaction of the RGD-functionalized scaffolds with the host immune system enhances bone regeneration and mechanical properties over 12 weeks. These findings have implications for regenerating quality bone for the insertion of dental implants in patients with significant alveolar bone loss. |
| Proceedings Inclusion? |
Planned: |