| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
In-situ AFM Identification of Mechanical Properties of Collagen Fibrils and Extrafibrillar Matrix in Bone |
| Author(s) |
Wei Gao, Xiaodu Wang, Heber Barron |
| On-Site Speaker (Planned) |
Wei Gao |
| Abstract Scope |
Bone is a natural composite material with a hierarchical structure consisting of three major components: mineral, organic matrix, and water. Water is present in three different compartments in bone matrix: freely mobile water in pores; bound water at the surface of the collagen fibrils and between the collagen and mineral phase; and structural water as part of collagen and mineral molecules. Water in every compartment contributes to different mechanical properties of the bone. It is known that bound water is present in both mineralized collagen fibrils (MCF) and extrafibrillar matrix (EFM). However, it is not clear on how bound water would affect the in situ mechanical behavior at the ultrastructural compartments. In this talk, we will present the effect of bound water on the mechanical properties of individual MCF and EFM under both dry and wet conditions using a high-resolution atomic force microscopy (AFM). |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |