| About this Abstract |
| Meeting |
2022 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biological Materials Science
|
| Presentation Title |
Use of Freeze-casted Fluorohydroxyapatite as an Osteogenic Bone Substitute |
| Author(s) |
Tony J. Yin, Sujee Jeyapalina, Steven E. Naleway |
| On-Site Speaker (Planned) |
Tony J. Yin |
| Abstract Scope |
New bone substitutes are needed to meet the ever-increasing demand for orthopedic and dental reconstruction surgeries. These substitutes require a porous structure to allow for vascularization, specific mechanical and dissolution properties to support bone regeneration, the ability to load-bear for preventing stress shielding related bone resorption, and biocompatibility to promote bone growth. Porous fluorohydroxyapatite (FHA) scaffolds made through freeze casting were assessed for their efficacy as potential bone substitutes. The resulting scaffolds showed mechanical strengths comparable to human trabecular bone and in vitro tests showed increased osteoblast proliferation on these FHA scaffolds. Bone growth on the porous FHA scaffold was further explored through coating the scaffold with different growth factors such as bone morphogenic proteins (BMPs) and transforming growth factor beta (TGF-β). Initial data showed that porous FHA scaffolds made through the freeze casting technique have the potential to be an engineered bone substitute. |
| Proceedings Inclusion? |
Planned: |
| Keywords |
Biomaterials, Mechanical Properties, Other |