| About this Abstract |
| Meeting |
2020 TMS Annual Meeting & Exhibition
|
| Symposium
|
Biodegradable Materials for Medical Applications II
|
| Presentation Title |
B-4: Discovery of Alloying Elements and Processing Parameters that Impart Improved Biocompatibility of Zinc-based Medical Implants |
| Author(s) |
Lea Morath, Alexander A. Oliver, Katie Flom, Roger Guillory, Jeremy Goldman, Eshan Mostaed, Jaroslaw Drelich |
| On-Site Speaker (Planned) |
Lea Morath |
| Abstract Scope |
Conventional metal stents remain in a treated artery for the lifetime of the patient. The permanent presence of foreign material is associated with harmful side effects. Bioresorbable stents that provide mechanical support during the healing phase and then harmlessly degrade may avoid the long term side effects. The interdisciplinary research team at Michigan Tech has been developing bioresorbable zinc alloys for stenting. An in vivo rat arterial implantation model was used to evaluate the biocompatibility of four new zinc alloys, two of which were thermal treated to improve structural characteristics. The explants were collected at six months, cryo-sectioned and histologically stained with H&E and VVG. Each cross section was measured for base neointimal length, protrusion of the implant into the lumen and neointimal area, metrics used to characterize the in vivo response. Results revealed favorable vascular responses to selected zinc alloys and thermal processing as compared to pure zinc. |
| Proceedings Inclusion? |
Planned: Supplemental Proceedings volume |